actemra dose calculator
They may use a dosing calculator to calculate your Actemra dosage based on your body weight. Reduction of dose from 8 mg per kg to 4 mg per kg is recommended for management of certain dose-related laboratory changes.
Dosing Schedule For Ra Treatment Actemra Tocilizumab
If you have rheumatoid arthritis or giant cell arteritis GCA you can receive Actemra via either.
. ACTEMRA changes the way your immune system works. Each light chain and heavy chain consists of 214 and 448 amino acids respectively. You can calculate the dose the number of SIMPONI ARIA single-use vials and the total volume of SIMPONI ARIA solution needed based on the recommended dosing of 2 mgkg and the patients weight.
The recommended dosage for ACTEMRA SC is the same in both treatment devices. For RA SLE DMPM PsA symptomatic sarcoidosis nephrotic syndrome and ophthalmic diseases. Some people have serious infections while taking ACTEMRA including tuberculosis TB and infections caused by bacteria fungi or viruses that can spread throughout the body.
The treatment frequency varies by indication. ACTEMRA changes the way your immune system works. The ACTEMRA prefilled syringe is a single-dose and is manually injected.
40 to 80 units 05 to 1 mL given intramuscularly or subcutaneously every 1 to 3 days. ACTEMRA SC is available in a prefilled syringe or the prefilled ACTPen autoinjector. These injection-site reactions were mild to moderate in severity.
Calculate the dose total volume of reconstituted REMICADE solution required and the number of REMICADE vials needed. Resume at every other week and increase frequency to weekly as clinically appropriate. Your healthcare provider should do blood tests before you start receiving ACTEMRA.
RA or SSc-ILD IV. Some people have serious infections while taking ACTEMRA including tuberculosis TB and infections caused by bacteria fungi or viruses that can spread throughout the body. Reconstitute each 100-mg REMICADE vial with 10 mL of Sterile Water for Injection USP to obtain a concentration of 10 mgmL using a syringe equipped with a 21-gauge or.
IV infusion dosing for RA. Recommended dosing from the label 1. Verify the patients weight and indication then locate it on the chart to find the corresponding dose and recommended.
The single-dose ACTPen autoinjector is a pen-like autoinjector that keeps the needle tip shielded before the injection allowing you to inject by holding down a button. In the open-label extension over an average duration of 73 weeks of treatment the overall rate of. If you have rheumatoid arthritis RA or giant cell arteritis GCA or systemic sclerosis-interstitial lung disease SSc-ILD your healthcare provider should do blood tests 4 to 8 weeks after you start receiving ACTEMRA for the first 6 months and then every 3.
RA GCA or SSc-ILD SC. See Full Safety and Boxed Warnings for more information. Infusion-related reactions are defined as all.
For example a person weighing 75 kg about 165 lb would receive 300 mg of. The majority resolved without any treatment and none necessitated drug discontinuation. WEIGH PATIENT AND CALCULATE ACTEMRA DOSE BASED ON INDICATION Actemra dosing is calculated based on each patients weight and the indication for which they are treated.
Resume at 4 mgkg and increase to 8 mgkg as clinically appropriate. In the 12-week controlled phase the rate of all infections in the ACTEMRA-IV group was 345 per 100 patient-years and 287 per 100 patient-years in the placebo group. This can make you more likely to get infections or make any current infection worse.
All 3 patients had ACTEMRA-IV dose interrupted 2 patients or discontinued 1 patient for the MAS event received treatment and the MAS resolved without. 80 to 120 units 1 to 15 mL given intramuscularly or subcutaneously daily for 2 to 3 weeks. The rate of infections was 2002 per 100 patient-years in the ACTEMRA SC weekly group and 1602 per 100 patient-years in the ACTEMRA SC every other week group as compared to 1560 per 100 patient-years in the placebo 26 week prednisone taper and 2102 per 100 patient-years in the placebo 52 week taper groups.
Find the ACTEMRA dosing calculator that can help determine dosing for polyarticular juvenile idiopathic arthritis treatment. WEIGH PATIENT AND CALCULATE ACTEMRA DOSE BASED ON INDICATION Actemra dosing is calculated based on each patients weight and the indication for which they are treated. Hold dose then resume when ANC 1000 cellsmm 3.
If you have rheumatoid arthritis RA or giant cell arteritis GCA or systemic sclerosis-interstitial lung disease SSc-ILD your healthcare provider should do blood tests 4 to 8 weeks after you start receiving ACTEMRA for the first 6 months and then every 3 months after that. 162 mg per 09 mL. The recommended dosage of ACTEMRA for adult patients given as a 60-minute single intravenous drip infusion is 4 mg per kg every 4 weeks followed by an increase to 8 mg per kg every 4 weeks based on clinical response.
This can make you more likely to get infections or make any current infection worse. ACTEMRA tocilizumab is a recombinant humanized anti-human interleukin 6 IL-6 receptor monoclonal antibody of the immunoglobulin IgG1 gamma 1 kappa subclass with a typical H2L2 polypeptide structure. Volume of the ACTEMRA injection required for the patients dose from the infusion bag or bottle 04 mLkg and 06 mLkg for 8 mgkg and 12 mgkg dosages respectively Step 2.
If you have polyarticular juvenile idiopathic arthritis PJIA you. The usual IV infusion dosing of Actemra for RA is 4 mg per kg given once every 4 weeks. More than one vial may be needed for a full dose.
Patients using ACTEMRA for subcutaneous administration should be instructed to inject the full amount in the prefilled syringe 09 mL or the full amount in the ACTPen autoinjector 09 mL which provide 162 mg of ACTEMRA according to the directions. The treatment frequency varies by indication. Verify the patients weight and indication then locate it on.
The ACTEMRA dosing calculator can determine ACTEMRA tocilizumab dosage for systemic juvenile idiopathic arthritis treatment. For use w systemic corticosteroids in hospitalized pts w suspected or confirmed COVID-19 requiring supplemental oxygen mechanical ventilation or extracorporeal membrane. In SC-II the frequency of injection-site reactions was 71 31437 and 41 9218 for the every other week ACTEMRA-SC and placebo-SC groups respectively.
Dosing Guide for Actemra tocilizumab IV for RA pJlA and sJl PART - INTRAVENOUS ADMINISTRATION OF ACTEMRA BY INFUSION This guide will walk you through the Actemra infusion process in steps 1 WEIGH PATIENT AND CALCULATE ACTEMRA DOSE BASED ON INDICATION Actemra dosing is calculated based on each patients weiqht and the indication. Various Special Note COVID-19 FDA emergency use authorization EUA Info. Resume at 6 mgkg.
Use the calculator below to determine the dose required for each patient. The Actemra dosage for giant cell arteritis in adults is a 162-mg injection either once per week or once every other week. Enter the patients weight in pounds or kilograms and click Calculate Dose.
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